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Roseola (roseola infantum, exanthema subitum, sixth disease) is an illness caused Never sponge a child (or an adult) with alcohol; the alcohol fumes may be. The spectrum of human herpesvirus 6 infection: from roseola infantum to adult disease. Most persons acquire HHV-6 infection by age 2 years, and HHV-6 infection is a common cause of fever and febrile seizures in infants.